Prime Minister Theresa May will trigger Article 50 proceedings with the European Union on March 29, launching two years of negotiations that will reshape the future of the country and Europe.

May’s government said her permanent envoy to the EU Tim Barrow had informed European Council President Donald Tusk of the date when Britain intends to invoke Article 50 of its Lisbon Treaty – the mechanism for starting its exit after a referendum last June in which Britons voted by a 52-48 percent margin to leave the bloc.

The EU said it was ready to begin the negotiations and within 48 hours of the trigger on March 29, Tusk will send the other 27 member states his draft negotiating guidelines, which means that talks could start at the earliest in May.